Elaine Fuchs (Rockefeller, HHMI) 1: Skin Stem Cells: Their Biology and Promise for Regenerative Medicine

Elaine Fuchs (Rockefeller, HHMI) 1: Skin Stem Cells: Their Biology and Promise for Regenerative Medicine

Recording date: 11/07/2018
Viewed: 2 times

Skin stem cells have great potential for the treatment of burns and corneal injuries. As Elaine Fuchs explains, understanding skin stem cell biology is also key to understanding cancers such as squamous cell carcinoma. https://www.ibiology.org/development-and-stem-cells/skin-stem-cells Talk Overview: Part 1 of 3: Dr. Fuchs begins her talk with a brief history of stem cells including the discovery in the 1970s that adult skin stem cells could be cultured in vitro indefinitely. This early work provided the foundation for later advances in embryonic stem cell (ESC) culture. ESCs are special because they can generate all the different tissues of the body, thus providing great potential for use in regenerative medicine. The use of ESCs is controversial, however, so scientists have developed ways of generating pluripotent stem cells that do not use embryonic tissue. Fuchs reviews methods such as nuclear transfer and the generation of induced pluripotent stem cells (iPSCs) by reprogramming adult somatic cells. Cells generated by these methods may be used for drug and therapy screening and they may provide treatments for human diseases such as macular degeneration, Parkinson’s and other degenerative diseases. Speaker Biography: Elaine Fuchs is the Rebecca C. Lancefield Professor of Mammalian Cell Biology and Development at The Rockefeller University and an Investigator of the Howard Hughes Medical Institute. Her lab studies the role of skin stem cells in homeostasis and wound repair and how these processes go awry in cancer and inflammatory diseases. Fuchs received her BS in chemistry from the University of Illinois, Champaign-Urbana and her PhD in biochemistry from Princeton. She developed her interest in skin biology as a post-doctoral fellow with Howard Green at the Massachusetts Institute of Technology. Before joining Rockefeller University in 2002, Fuchs was a faculty member at the University of Chicago for twenty years. Fuchs’ many contributions to skin and stem cell biology have been recognized with myriad awards and honors including the National Medal of Science in 2008, the March of Dimes Prize in 2012, and the E.B. Wilson Prize from the American Society of Cell Biology in 2015, to name a few. She is a member of the National Academy of Sciences and the National Academy of Medicine. Learn more about Dr. Fuchs’ research here: https://www.rockefeller.edu/our-scientists/heads-of-laboratories/1166-elaine-fuchs/ http://www.hhmi.org/scientists/elaine-fuchs

Elaine Fuchs (Rockefeller University & Howard Hughes Medical Institute)


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