Jeannie Lee (Harvard) 2 - X Chromosome Inactivation: Making the Right Choice

Jeannie Lee (Harvard) 2 - X Chromosome Inactivation: Making the Right Choice

Recording date: 08/05/2019
Viewed: 3 times

https://www.ibiology.org/development-and-stem-cells/x-chromosome-inactivation The X chromosome is many time larger than the Y chromosome. To compensate for this genetic inequality, female mammalian cells undergo X chromosome inactivation of one X chromosome. Dr. Jeannie Lee explains the how and why of X chromosome inactivation. Part 2 of 3: In her second talk, Lee elaborates on the early steps of X inactivation. Very early in development, cells “count” the number of X chromosomes and decide if one needs to be inactivated, and if so which one. There is a region of the X chromosome called the X inactivation center which is enriched in long non-coding RNAs (lncRNAs). Lee explains how she and others showed that by sensing the ratio of two specific lncRNAs the cell can determine how many X chromosomes are present. Further studies showed that two different lncRNAs are responsible for randomly determining which X chromosome will be inactivated. Finally, she discusses the hypothesis that the allelic choice mechanism depends on a transient chromosomal pairing event that occurs at the beginning of the dosage compensation process. Speaker Biography: Dr. Jeannie Lee is a Professor in the Department of Genetics at Harvard Medical School and in the Department of Molecular Biology at Massachusetts General Hospital (MGH). Her lab uses X chromosome inactivation as a model to study epigenetic regulation by long noncoding RNAs. Lee received her AB in biochemistry and molecular biology from Harvard University and her MD/PhD from the University of Pennsylvania School of Medicine. She was a postdoctoral fellow at the Whitehead Institute and a resident at MGH before joining Harvard/MGH as a faculty member in 1997. Lee was also an HHMI Investigator from 2001-2018. She is a member of the National Academy of Sciences and a Fellow of the American Association for the Advancement of Science. Lee has been honored with numerous awards including the 2016 Centennial Prize from the Genetics Society of America, the 2016 Lurie Prize from the Foundation for the National Institutes of Health, and the 2010 Molecular Biology Award from the National Academy of Sciences. In 2018, she was President of the Genetics Society of America. Learn more about Dr. Lee’s research here: https://www.x-inactivation-lee-lab.org

Jeannie Lee (Harvard Medical School, Massachusetts General Hospital)


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